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    In the primary efficacy analysis, complete or major control of emesis (0 to 2 emetic episodes) between days 1 and 3 was seen in 80 of ot and 78 of odt patients. The taste of odt was acceptable to the majority of patients (89) who received it. In the secondary efficacy analysis, no significant differences were observed in the rates of complete control of emesis (no episodes of emesis) over 3 days (63 and 64 of the respective groups) and on day 1 (84 and 81, respectively) and in the complete control of nausea over 3 days (37 and 43, respectively) and on day 1 (59 and 61 of patients, respectively). . A total of 427 cancer patients receiving cyclophosphamide chemotherapy participated in this multicenter, double-masked, double-dummy, parallel-group, randomized study comparing the antiemetic efficacy and safety of an 8-mg conventional ondansetron tablet (ot, n 212) taken twice daily with an 8-mg orally disintegrating ondansetron tablet (odt, n 215) taken twice daily for 3 days. Thus 8 mg odt twice daily represents a palatable, well-tolerated, and effective antiemetic treatment for the control of cyclophosphamide-induced emesis and nausea and provides equivalent treatment to ot 8 mg twice daily.

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